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KMID : 0388120120210010057
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Journal of Korean Society for the Study of Obesity
2012 Volume.21 No. 1 p.57 ~ p.64
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The Effect of Visceral Fat Area and Adipocytokines on Acute Myocardial Infarction: A Case-Control Study in Adult Korean Population
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Lee Kang-Kon
Suh Young-Sung
Yum Keun-Sang
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Abstract
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Background: This study aimed to analyze visceral fat area (VFA) and the pattern of secretion of adiponectin, leptin, TNF-α, IL-6, and IL-10. It also studies the effect of VFA and adipocytokines on the risk of Acute myocardial infarction (AMI) in adult Korean population.
Methods: A patient group (PG) consisting of 121 patients, who were hospitalized for AMI from 2008 to 2009, and a control group (CG) consisting of 115 healthy adults, who visited the same hospital for health examination within the same period, were included in this study. Physical measurements were performed and VFA was measured using computed tomography. Lipid, metabolic index, adipocytokine levels were also measured after 12 hours of fasting.
Results: BMI, waist circumference, levels of leptin, TNF-α, and IL-6 were significantly higher in the PG, while adiponectin level was significantly higher in the CG. According to the comparison study analyzed by gender, VFA level was significantly higher in the PG, and IL-10 level was significantly higher in the CG. After adjusting for the conventional risk factors (CRF) of AMI, regression analysis showed that adiponectin and IL-10 levels reduced the risk of AMI; whereas VFA, TNF-α, leptin, and IL-6 increased the same risk.
Conclusion: It is postulated that adipocytokines and VFA will act as independent risk factors of AMI regardless of CRF of coronary artery disease.
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KEYWORD
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Myocardial infarction, Visceral fat, Adipocytokines
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